Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p066 | (1) | WCRB2014

The regulatory roles of let-7 in embryo dormancy in mice

Liu Weimin , Pang Ronald T K , Yeung William S B

Introduction: MicroRNAs interact with multiple mRNAs resulting in their degration and/or translational repression. Embryo diapause is a widespread phenomenon in which temporarily arrest occurred in embryo development. Our previous data showed that the levels of let-7 are relatively high in diapause embryos compared to reactivated embryos by E2 in mice. However, it is still not clear whether or not let-7 is involved in embryo diapause.Materials...

ra0002o006 | Oral Communications 1: Embryo and Implantation | SRF2015

Mechanism of microRNA lethal-7 in embryo dormancy in mice

Liu Weimin , Pang Ronald T K , Chiu Philip C N , Li Qian , Yeung William S B

Embryo dormancy (embryo diapause) is a reproductive strategy used by ~100 different mammals to avoid the risk of exposing their offsprings to unfavourable environmental conditions by delaying embryo implantation. The blastocysts from domestic sheep, rabbit or cattle enter into diapause after being transfer into mouse uteri induced to have delayed implantation. The observation suggests that blastocysts from all mammals, including that of human, may have an ability to enter into...